I've run Schwalbe Pro One tires on my road bike (with DA C24 TL wheels) for just about years now, and have gotten maybe 4 or 5 total unsealable flats in that time. Small punctures sealed up fine, and the flats came from big cuts that orange seal couldn't handle. When those happened, I just put in a regular tube, pumped it up (which re-seated the bead easily with a CO2 cartridge) and rode away like it was a regular clincher. Least trouble I've ever had. The Pro One tires aren't the longest lasting, but while they're in service, they have been pretty great all around, including racing and training. Thin tread though, so not ideal as a commuter tire.
Just started running the Vittoria Corsa Speed G+ tubeless tires on the TT bike in April, but instead of running tubeless, I decided to try latex tubes for the first time, just out of curiosity. After seeing a buddy at the state TT event last weekend get a puncture just before the start (and his sealant healed it), I'm wondering if it was perhaps the wrong idea for me to run tubes when the wheels (Hed +) and the tires are both tubeless ready. Time will tell. Will eventually switch over to tubeless on the TT bike as well I'm sure.
Just started running the Vittoria Corsa Speed G+ tubeless tires on the TT bike in April, but instead of running tubeless, I decided to try latex tubes for the first time, just out of curiosity. After seeing a buddy at the state TT event last weekend get a puncture just before the start (and his sealant healed it), I'm wondering if it was perhaps the wrong idea for me to run tubes when the wheels (Hed +) and the tires are both tubeless ready. Time will tell. Will eventually switch over to tubeless on the TT bike as well I'm sure.