there are newer saddles, such as BiSaddle, which you may not be familiar with, and we'll go thru how this saddle works.
Assuming there is just one version of the BiSaddle that works for both men and women?
In all seriousness though, do you have details on how/what is adjusted? Assuming it is similar to ISM, but with adjustments. Does that make it overly heavy compared to others?
I ride an ISM on my tri bike and either an Asute or Selle Italia on the road, but am always willing to try new things. I also think what you are wearing has a big influence on saddle comfort.
What you're wearing has a huge impact on comfort, as well as indoor vs. outdoor riding. In general, my feeling is saddle should be as firm as possible and high quality bib shorts and shammy should be as tight as possible.
From there, depending on the use case, you need to create a situation where there's more than one comfortable position on the saddle to interface with. It's possible to set your saddle height and setback high enough such that you only contact the saddle in one place in one way. Even the best fit on the best saddle and that will get old after awhile. On the road it's easy, as there's different dynamics going on... on the tops in the peleton, sitting way back on a climb, in the drops and/or descending, and then on the rivet off the front of the bunch. Each one of those is a different "position" for me and a different place to sit on the saddle. This is why I like a long flat saddle like the one I use. I couldn't imagine using my TT bike saddle for my road bike.
Trick with a TT bike is to get the saddle height and setback such that your knee angle is in the center of the range when you're contacting the saddle in the center of the saddle's range. That way, you can slide back slightly or slide forward slightly for comfort. These muscles should be trained as well.
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