I would highly recommend looking at Ultimate Direction vests. These vests are designed for running and work well for riding as well.

Full disclosure, I do work for the same company that owns UD, but I've been very impressed with the vests and bike commute with the SCRAM. It's a no frills pack, but has high functionality. I do have several Osprey packs, but I've happily traded up.

If you are running to work and carrying clothes, there are definitely some vests that can accommodate and provide stability in the pack as you run.

https://ultimatedirection.com/

jake

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Get outside!