I would rather work on your strength and mobility, in order to avoid injuries

You want to avoid injuries and gradually increase training - so far so good.

Running of the bike for your case:

• (+) you start warmed-up, so you mitigate an injury probability,
• (-) you start running exhausted, so the exercise load of the brick run is higher than comparable standalone run
• (-) you start running fatigued, so your form isn't at its best, so the impact load of the brick run is higher than comparable standalone run

I'd recommend focusing on warming-up properly, without fatiguing 2h rides before, e.g. I find an elliptical cross-trainer the perfect warm-up device before running.

Thanks. My thought was the fatigue help med keep the pace low, making me less prone to injuries, but what you are saying is I really need a proper warm up, and then run with a focus on keeping the pace low, not just the feeling?

If you have access to one, a Concept2 rower is also a really good warm-up machine before running. Another thing you can try is to pair run workouts with swim workouts, so you swim after running, ideally straight after but if that's not possible a few hours later also works quite well, to reduce soreness and promote recovery/healing. When you do run, choose flatter, softer surfaces if possible (golf courses and beaches are awesome). Also, I don't know how tall you are, so this may not be an option, but shedding any excess pounds really helps with avoiding injuries. When I run at 170 pounds it feels far harder than running at 160 pounds, even though 10 pounds is not really that much.

Unfortunately we havent got the space for a C2.
Regarding heigth I’m 193 cm (6’4”?).

I hope to loose more weight, have just lost 14 kg, but Im in a hope to be light enough to run again.

Dude 90kg at 6'4 is NOT heavy at all. I'm 89kg at 6 foot (plus a 42 year old office jockey) and still ran a sub 3 marathon last year. You don't need to shed a single gram just get out there and run

193 cm and 90 kg gives bmi 24.2, so if you are muscular, you probably don’t have much weight to lose. I find I train, race, and run best around a bmi of 23. Any lower and I get sick/injured more frequently. Higher, and I start running “heavy”. Good luck with the running.