It would only be more aero if it allows you to get lower in front. And then you still have to be able to power the bike through the air.
But as for whether the wheel itself is more aero... No. Anything you gain with the wheel you lose in longer frame tubes.
And then you have to carry 2 spare sizes.
Now I remember the REAL funny bikes... 700 rear and a 24" front. The Shogun Kaze... Fuji Team... (there's a shop near me that has a Fuji Team in mint condition with Shimano Sante... I'm tempted)
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