I wanted to touch on this. I've run the gamut of saddle discomfort, also had high hamstring discomfort that showed on an image but what we were primarily looking at was my hips (I'm 10 months PO from labrum/FAI repair). A thing I've learned is that I don't or at least certainly didn't engage my transverse abdominus very well. I've been focusing on that now for months and in doing so I notice a difference in how my soft tissue feels on the saddle and a difference in the amount of strain I feel in my hamstrings. I've been told I have overly flexible hamstrings but a stiff lower back. Basically I'd say I've had un-ideal pelvic tilt. (I ponder the influence of this on my swimming, wicked tight hip flexors, ...).

As another poster said, I find I want to either move my saddle forward or bring my bars back, and possibly up <gasp> as I'm not so good about holding the pelvic rotation over long efforts. Will re-engage with my fitter shortly.

Oh, and as a PS to the OP, I was also on a Cervelo (P2C). I could never have engaged my TA the way I'm trying to now while on my prior bike, the reach was just too long. And I was fit on the Cervelo many times. I'm unsure how good all fitters are at understanding our complaints on saddles, and again as already stated, they can't know what we look like as we fatigue.

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To breathe, to feel, to know I'm alive.