Yes. Once I hit a bump at Leon's Tri around 1990 & my custom low spoke front popped way out of true. Too tight of spokes I guess. Another time, a year or so ago, I hit a brick in the bike lane while keeping my head down. Rim bent & out of true. But those are my only experiences with out of true wheels. Except that time at IM CALI 2000 when I landed on my front wheel after a volunteer body checked me in transition. Okay. Three times. Seriously though, a well built wheel with proper tension should not pop out of true suddenly unless there is a material defect or otherwise cause like mine. It can get out of true with use. All the rough roads & bumps you hit over time can loosen the nipples over time. But from one second to the next, it doesn't sound like that is normal/common as much it is a material issue.