Scotttriguy wrote:
I just got my 23andme genetic results back this week - I ran the raw data through geneticgenie to get the 'mutation' report - I've been sick for over 8 months, zero training in that time - what I've learned this week - my B12, methylation and methionine cylces are deficient coz of the mutations: - mtr a66g homozygous - means got mutation from both parents, so double whammy - impedes use of B12 - my B12 (and folate) blood levels have been abnormal high for over a decade, but its just not getting converted to use in cells - I'm now on daily B12 injections and methylfolate (coz folic acid is synthetic).
I've also got other mutations, heterozygous, so mutation from just one parent including:
- 2 that affect Vitamin D use - so I'm now taking 5000 IU daily
- one that increases homocysteine
- another that increases taurine, ammonia and decreases BH4
and a few more that affect dopamine, glycine.
This knowledge gives me hope that I'll feel better through addressing these issues with supplements - and maybe even get back to training and racing.
Well worth my money.
Don't mean to hijack this thread, but just in case others read your post and start wondering about "genetic testing" - commercially available "gene" tests, like the "23andme" project do not detect disease causing mutations. They detect single nucleotide polymorphisms (SNP) (common variants in genes at particular locations in the DNA) in a few selected genes, which are known to be present at a certain % in certain populations, and that's how they can tell your ancestry. In particular, the MTRR A66G polymorphism just means that a % of the population is AG, and some are AA and GG. SNP are not mutations that cause disease, they are normal variants present in the population. They MAY be associated with an increased (or decreased) risk of disease or metabolic changes. This risk is modified by many things, such as diet, environmental effects etc and the effects or many other genes among others. Some polymorphisms in some genes are very strongly associated with significant disease risk (for example the risk of Alzheimer's with particular APOE variants) , others (like the MTRR 66AG/AA/GG variants) are of more uncertain link to disease. Hope you feel better soon.
Two wheels good. Four wheels bad.