Unexpected Cholesterol Increase Despite Clean Eating – Could Fasted Workouts Be the Cause?

Quick context: I’m a 39-year-old male, very healthy and athletic, with no family history of heart disease (though there is some diabetes and stroke on my dad’s side).

Before starting my Ironman 70.3 training, my cholesterol was high: 230 total, 184 triglycerides, 143 LDL. Through natural methods—training and eating clean—I lowered it to 180 total, 75 triglycerides, 103 LDL, 79 Apo(B), and an Lp(a) of 92 nmol/L. My glucose was also 96.

Recently, I made even more dietary improvements by cutting out most saturated fats for six weeks (no dairy, cheese, red meat, etc.). Despite that, my latest results surprised me: 193 total cholesterol, 114 triglycerides, 113 LDL, and my Lp(a) rose to 127.5 nmol/L. Additionally, I have abnormal LDL particle numbers, especially small particles, and my glucose slightly increased to 104. My CAC score is 0, and I’m scheduled for a heart stress test and carotid artery ultrasound soon.

While my doctor and cardiologist don’t see this as an immediate cause for concern, they’ve flagged the elevated Lp(a) as an independent risk factor for cardiovascular disease (CVD), which could accumulate over time.

My new primary care doctor, who focuses on nutrition, suggested that my elevated readings—despite eating clean—might be linked to not eating enough, especially before morning workouts. I often skip breakfast before runs or rides and end up fueling during the workout with gels or sports drinks. Post-workout, I’m usually ravenous, particularly at night, craving carbs or sugar.

She believes my LDL issues could improve by eating a bigger breakfast and spreading meals more evenly throughout the day. The theory is that my liver might be overproducing small LDL particles due to metabolic stress from not consuming enough calories or macros, particularly before workouts. Has anyone experienced something similar?

I’ve often seeing it said if you have a strenuous workout in the three days before getting tested, it can throw off your lipid panel results

On another point by any chance, have you had a coronary calcium scan? You may wanna look into it if your cholesterol is been high in the past.

yep CAC fortunately was 0 but have been traveling a lot so maybe part of it is Jetlag stress.

I only looked at the first one listed but it really doesn’t pass the sniff test for me.

Results: The study showed that reducing total saturated fat intake could decrease the risk of cardiovascular events by approximately 17% but had no effect on the risk of dying from heart disease or other causes.

More specifically, replacing some saturated fat with polyunsaturated fat in the diet led to a 21% lower risk of cardiovascular events, while replacing saturated fat with carbohydrates was linked to a 16% lower risk.

"Conclusion: People who reduced their saturated fat intake were just as likely to die from heart disease and other causes as those who ate more saturated fat.

However, partially replacing saturated fat with polyunsaturated fat or nutrient-dense carbohydrates, such as whole grains, may be beneficial for heart health and disease prevention.“”

The next thing you’ll be spouting is your demonizing take on seed oils again.

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why you cut red meat?, you should cut process food (everything that comes in a box, can or plastic bag), as simple as that.

230 is not high

all the problems lie in refined sugar and refined oils mostly

His own article even says: “People with certain medical conditions or cholesterol problems may need to monitor their saturated fat intake.”

Eating less saturated fat will often reduce LDL numbers. Whether that’s worth doing - depends on what yours is at, and family history, etc.

My numbers were up a little at my last checkup so I switched to a vegan diet just to see how much it would affect things. I did another lab 3 months later. Result was:

Total: 175 (prev: 222, target: <200)
HDL: 44 (prev: 49, target: >40)
LDL: 114 (prev: 155, target: <100)
Non-HDL: 131 (prev: 173, target: <130)

The diet doesn’t bother me and I’d rather avoid statins if the dietary changes are working.

So you didn’t bother reading the other studies for the overall meta-analysis conclusion. Surprised spudone a vegan, gave a better response than you.

Mine was more of an n=1 but thanks. I know it’s not directly what the OP was after. I haven’t had an LDL particle test so I don’t know where I stand on that.

My plan is to add back in a few things (fish, chicken) then re-check my numbers in another 3 months until I find a good balance.