“We tried to see what was the minimal dose that he could tolerate without losing any more weight,” says Isaacson of the former Olympian, who had already been on a new diet and nutrition regimen. Over months, the athlete gained muscle, improved his VO2 max, a measure of aerobic capacity, and lowered his risk for neurodegenerative disease. “Everything about his everything improved.”
The next form of tested PED or just like caffeine?
What drug where they using ?
Zepbound.
“ After reducing the dosage, Isaacson arrived at 0.75 milligrams as a “sweet spot” with no negative side effects. Test results, running logs, and body composition analyses over the next year show many of his health markers went from good to great: His cholesterol, muscle mass and VO2 max improved. He stopped craving Girl Scout cookies. And this January, he ran his best half-marathon in 15 years—10 minutes faster than his last one.”
Similar to Mounjaro in the US and Canada
REALLY expensive. Like $400-500 per month
Looking at GLP-1’s all I can think about is Fen-Phen and how that ended in tears.
I read a thread on Reddit about a guy using (I think) retatrutide and indicated it could have performance enhancing effects. I think these will end up getting banned by WADA at some point.
Maybe. On the nero show, so certainly not a scientific study but an interesting datapoint, they talked to a guy who used ozympic for a month to help get his weight back under control. Lost weight but his ability to train was massively compromised. Not sure something like that is a PED for an already elite athlete. I guess all im saying is it probably depends on the drug
Looks so safe
Important Safety Information. Select to Expand.
Warnings - Zepbound may cause tumors in the thyroid, including thyroid cancer. Watch for possible symptoms, such as a lump or swelling in the neck, hoarseness, trouble swallowing, or shortness of breath. If you have any of these symptoms, tell your healthcare provider.
Zepbound may cause serious side effects, including:
Severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use Zepbound. Tell your healthcare provider if you have stomach problems that are severe or will not go away.
Kidney problems (kidney failure). Diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems. It is important for you to drink fluids to help reduce your chance of dehydration.
Gallbladder problems. Gallbladder problems have happened in some people who use Zepbound. Tell your healthcare provider right away if you get symptoms of gallbladder problems, which may include pain in your upper stomach (abdomen), fever, yellowing of skin or eyes (jaundice), or clay-colored stools.
Inflammation of the pancreas (pancreatitis). Stop using Zepbound and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back.
Serious allergic reactions. Stop using Zepbound and get medical help right away if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue or throat, problems breathing or swallowing, severe rash or itching, fainting or feeling dizzy, or very rapid heartbeat.
Low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use Zepbound with medicines that can cause low blood sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood sugar may include dizziness or light-headedness, sweating, confusion or drowsiness, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, mood changes, hunger, weakness or feeling jittery.
Changes in vision in patients with type 2 diabetes. Tell your healthcare provider if you have changes in vision during treatment with Zepbound.
Depression or thoughts of suicide. You should pay attention to changes in your mood, behaviors, feelings or thoughts. Call your healthcare provider right away if you have any mental changes that are new, worse, or worry you.
Food or liquid getting into the lungs during surgery or other procedures that use anesthesia or deep sleepiness (deep sedation). Zepbound may increase the chance of food getting into your lungs during surgery or other procedures. Tell all your healthcare providers that you are taking Zepbound before you are scheduled to have surgery or other procedures.
Common side effects
The most common side effects of Zepbound include nausea, diarrhea, vomiting, constipation, stomach (abdominal) pain, indigestion, injection site reactions, feeling tired, allergic reactions, belching, hair loss, and heartburn. These are not all the possible side effects of Zepbound. Talk to your healthcare provider about any side effect that bothers you or doesn’t go away.
Agree. At a minimum, I’m also worried that engaging in an endurance sport and taking appetite suppressant (if I understand these properly) is essentially setting your body up for failure in the future.
But ya, when people’s various organs start failing or other issues arise, there will be a lot of complaints about crooks and no evidence and finger pointing etc.
I can see an argument for obese people very unhealthy that the unknown side effects aren’t worse than the known effects of their current state. But for an athlete who is already stressing their bones, muscle, heart, liver, etc… crazy.
Here is that thread FYI. I think I misrepresented his intent though, apparently he is/was on the phase 3 trial, but it sure read as though he would continue for performance enhancement. https://www.reddit.com/r/Retatrutide/comments/18997fy/comparing_the_big_3_sema_tirz_reta_a_moderate/
Wow, thanks for sharing, so many people neglect to read the manufactures inserts and side effects warnings of drugs/vaccines and inherently believe they are safe because they’ve received regulatory approval.
GLP-1, semaglutide, etc. are on the 2025 WADA monitor (pre-ban) list.
If it comes to the point of being banned and if one is truly diabetic, does this work like Insulin, where you don’t get a TUE but if you are flagged you show your medical condition ?
I’m no longer in the testing pool and I never had a TUE. So, anecdotally, IDK.
Maybe Google: WADA + USADA + drug name + TUE
replying to thread:
I’ve been experimenting with my weight vs race times ever since I found this calculator for the past 7 months: Weight vs Pace Calculator | runbundle
I’ve been doing it the hard way without these drugs by maintaining a daily caloric deficit of 700 calories. I did this for a 6 month marathon block training cycle. I lost 15 lbs and chopped 9 minutes off my PB open marathon time (3:02 to 2:53).
I did this while maintaining a very high protein intake (120-150 g/day) and fueling all workouts with high carb (40-100g/hr).
I was a BMI of 25.4 and ended around 23.3. Body fat of around 22% to 16%. I specifically point this out because I do not believe anyone with an already low BMI and body fat would have seen the same results.
The weight loss came entirely from fat loss, my ftp and critical run speed significantly improved.
It was freaking hard. I was so hungry all the time outside of workouts. If I could have had a drug to reduce the hunger it would have made this so much easier and enjoyable.
I bet you as long as you prioritize protein and fueling workouts these drugs would not have nearly the same performance side effects during training.
Yup, these drugs make this part so easy. A very large segment of the US population should be on GLP1’s and will be on GLP1’s over the next decade. They will drastically improve the health and quality of life for so many people.
From a performance perspective it’s an entirely different conversation and I would not be surprised if they were banned sooner rather than later.
They reduce gastric emptying, it wouldnt be possible to fuel your workouts like that
in the article it talks about microdosing. There is a paragraph where a guy found an amount that reduced his hunger so he could still fuel workouts.
GLP drugs have been used for 2 decades now. Have there been a lot of organ failures noted in any studies?
They have but now are being prescribed to a vastly broader cohort of people were the long term effects are entirely unknown.