I’d be very careful running in it. Our joints aren’t designed to be carrying a bunch of weight while running outside of our body weight.
Very rarely do I say anything is bad for everyone, so I’m sure there would be an appropriate use for this vest, and you might be that one, but I know my joints wouldn’t be pleased with me if I tried running in it.
Personally, I’ll say that I think there would be little benefit, and the risk associated with that benefit probably isn’t worth it for most people.
When I was prompted to get it, it was to help with economy during track workouts. What we wound up doing with it was wearing it with just a little extra weight (8-12 LBS + the weight of the vest, about 2 lbs) and doing 10k x 2 in it or shorter runs around zone 2 or LT.
my old boss would just commute in with it on and walk around the shop with it. never any actual training rides/runs. and I agree with one of the other posters… don’t run with it on your joints really can’t tolerate that.