I would get a place close to work less than 5-10 miles as traffic will be your living hell ( odd hours could help 6am -3pm ). Most of the beach areas - Pac. Beach - Ocean beach - Del mar $$$ - leucadia - encinitas -solona beach - Cardiff are great but expensive Major traffic / parking issues in the summer.
Places to avoid in north county “Vista & Oceanside” more than a few Wackos live there , 70% of violent police calls are to that area.
Tons on middle and higher income areas to the north county Poway - Escondido , most were built without enough road capacity for the homes . The morning commute to 15 can be bad , but they are widening areas continuously on 15.
You wont find anything cheap , but some pockets can be less expensive . To the south " east lake " chula vista area is the fastest growing . The hardcore country folk ( trucks -horses -guns ) live in Santee -lakeside - El cajon , El cajon can be rough / a bit more crime low end neighborhood is near the court / jail building .
Hillcrest - Kensington - mission hills - have been renewed / rebuilt by young professionals and Gay couples a clean safe area . These are more or less the center / east of town , with a short drive to the airport - harbor - gas lamp - Ball park - Old town . These would be great for people who get plenty of visitors / business related entertaining .
Off of Highway 8 east of san diego state uni., La mesa - lemon grove - varies from middle to low income areas Mount Helix being the $$$ highlight of that area . The rule use to be north of 8 were better areas , as long as your a few block away from El cajon blvd the south side can be "OK " still low end .
On the south side of 8 and El cajon Blvd to highway 94 , there is a patch of Pakistan -Somalia - Philippine immigrants near the college grove shopping center. five years ago it wasn’t uncommon to find more than one spot of scattered 9mm casing while biking down El Cajon blvd.
Heres a tip , you get more sun east of highway 15 ( another highway to hell ) . We have June gloom , overcast clouds till 10am - 12 noon . If your a sun worshiper you get it 50% more east of 15 , that "could "be two weeks at 108 degrees in august as its mostly 5 -10 degrees hotter than the coast.
I would get an apartment in mission valley live there for six months , to get a lay of the land . Its all about what you can afford and where you work .
There are more than a few San diego folks posting here , So if you get more detailed questions someone here will know.
Heli