PRP injections for chronic mystery knee problem

Hi everyone,

I’m a 52 year old from London. I’m primarily a runner (1:27 HM time) but also do tris, and completed my first 70.3 in Cascais in 2019. Hoping to return to the distance in Estonia this year.

I posted a few months ago about Hylauronic acid injections for a chronic knee issue that’s now been bothering me for ten months or so – thanks to all who replied. In the end, I didn’t receive them as the ortho worried they may cause a joint flare.

Since then I’ve seen a sports medicine Dr who’s highly regarded and was recommended personally by a physio friend with with no ulterior motives. He’s suggested trying a leucocyte-poor PRP injection, with the caveat that it may not work. If it does, he’d suggest a second. So I thought I’d now see if any STers with knee issues have experience – positive or negative with PRP.

Has it helped you? And what is the recovery time? Obviously, I say this with usual caveat that no one can diagnose me virtually – everyone’s experience is unique.

Quick background. Living in NYC in 2006, I overtrained for the Philadelphia Marathon and developed some mild but persistent knee pain. MRIs were clear. However, I was talked into ‘exploratory’ knee surgery because ‘MRIs don’t show everything’. Under the knife, I was given a plica removal and small partial meniscectomy. The surgeon assured me I’d be on my feet for an intensive job three weeks later, that I didn’t need physio, that I’d be doing a tri three months later, and that - whatever happened - I wouldn’t be in greater pain after the procedure.

He left me unable to walk, with severe pain and swelling, and washed his hands of me once he’d collected my insurance money. I required a second operation six months later to remove scar tissue that locked my knee, and it took 8 months of intensive physio to return to even gentle running.

That was a massive success. I’ve never run a marathon since, but I’ve returned to all other distances, needing only maintenance physio to keep my leg strong, and I as I say, did a 70.3 in 2019.

Last July I woke in the middle of the night with deep, throbbing medial joint line pain. Running was ok at first, but I soon found that I’d have sharp, stabbing medial pains an hour or so after training. These pains then started bothering me on the run itself, and I had to stop for a month. The down pedal stroke on the bike became painful.

My immediate thought was that I’d finally succumbed to the dreaded post op arthritis - but two MRIs and two opinions from excellent Drs have shown that while my knee cartilage is far from pristine and I have some small chondral defects, it’s in good shape for my age and activity level, and that there shouldn’t be any reason I can’t train or compete. My meniscectomy was apparently (thankfully) very small.

I’ve now done 10 months of physio. I’ve tried everything suggested – and while I can run, I have regular ongoing sharp medial pains during the run and after, have no confidence increasing my intensity, and night pains continue to disrupt my sleep.

As I mentioned, HA was discussed, but not given. That ortho sent me on my way saying I’d be fine long term. But I know this knee, and I’m far from fine – so I’ve ended up at the sports Dr who suggested PRP (with the caveat that it wasn’t a magic bullet.) He also said I may have chronic medial compartment overload and nerve sensitivity, and suggested amitriptyline to reduce this response.

If you read this far – thanks!  I’m basically wondering whether PRP has helped those with meniscal/chondral issues in their knee, or has made you worse/made no improvement? I know the scientific evidence is increasingly positive for PRP, but seemingly not yet conclusive.

And how long did you hold off activities afterwards? The sports Dr has said I should rest for between 4-6 days, but otherwise can live life as normal.

However, other recovery protocols I’ve read have said no running or heavy physio for as long as three months post injection. I’m adopting a dog 8 days after the proposed first injection date, so really need to be able to walk without issues!

Hope you’re all doing well – thanks for any insights.

Cheers, Will

Anecdotally I have 3 friends in their 60s-70s who have each tried PRP injections for stubborn knee pain in the last 3 years or so. Sadly, none of them has experienced improvement.

Thanks for the reply. That’s sad to hear, but not surprising. PrP and other injections seem to often be marketed as a miracle solution.

But that doesn’t exist, and at least the Sports Dr I spoke to was very honest and realistic on that front…

Another anecdote here from slowtwitch. We’ve had 2-3 members talk about their miracle knee injections. None of them have come back here to tell us it helped them resolve their issues.

Thanks - well if I have the injections I’ll report back as well. Just keeping fingers firmly crossed that they don’t make me worse.

I think the moral of my story for anyone - athlete or not - is to stay as far as possible from rogue orthopaedic surgeons, especially in the profit driven US healthcare system, and always, always get a second opinion on any procedure suggested. Since my experience I’ve heard so many horror stories.

I look back at what my first surgeon in NYC promised now (including being back at a job that required me to be on my feet for over 12 hours a day only three weeks post surgery) and I’m just astonished both that he had the gall to lie to me so brazenly, and that was I so naive as to believe him.

He’s still practising - I’d be happy to share his name via PM with anyone considering surgery in NY.