Anyone run in the 4’s and 5’s? It is time for a replacement and some reviews I have seen say that the 5’s is a much different (stiffer and not has cushioned) shoe than the 4.
I think the 6 is out now too. Maybe that is more like the 4.
I run in the Vomero’s and was a little nervous about going from the 4 to 5 because they look so different.
Really there is not much difference as far as feel goes. Still the same soft running shoe as the 4.
The only thing I thought I noticed was the heel did not feel quite as snug and it was not even really a big issue.
I would be 95% confident you will be just fine with the Vomero 5.
You could even jump ahead and get the Vomero 6 and tell us all what you think of it. 
I was fine in the 2’s, 3’s, and 4’s, but the 5’s kill one of my toenails (middle toe - not the big toe or the second/longer toe). I have orthotics, so I can’t really comment on the cushioning - I didn’t notice any difference, though. They feel stiffer, and there’s more fabric across the top so that it bunches up when I tighten the laces. However, the other shoes I tried just killed different (and more) toenails. I’m hoping the 6 will be better and become my new favorite shoe.