I’m not following what you mean regarding “causing more morbidity and death with unnecessary follow ups.â€
For example, you’ve got on older man, blood test shows PSA elevated. Instead of just letting it be, an aggressive approach might be to do a biopsy fearing it could be cancer. Biopsy damages the pudendal nerve and now the guy is impotent, or he gets an infection that goes septic and dies.
Turns out it was just a typical benign enlarged prostate causing the PSA elevation.
Another issue is let’s say it turns out to be cancer that was caught early by the blood test…but turns out survival is no better for people where it’s caught early with the blood test than it is with people where it’s caught later when they become symptomatic. I think this was the problem with one of the blood tests they tried for colorectal cancer.
Oh yes as a patient gets older I can understand age and comorbidities as risk factors and a calculated decision must be made.
But we’re still talking about risk vs reward first. When there are treatment options available whether for quality of life, extending life, or curing the disease, I think it’s quite valuable to take some risks of potential complications when the risk of doing nothing is undiagnosed and untreated cancers (in many situations).
For instance, elevated PSA is indicative of cancerous lesions in 25-30% of cases. That’s a big gamble to say “well it’s elevated PSA which can mean >1 in 4 risk risk of cancer but there are potential complications from further testing so we’re not going to pursue those at this time.
I’m sure there are those who would forego treatment if the prognosis is inevitable. However I also know there are those who would try treatment to prolong life and QOL.
My brother in law was already stage 4 when diagnosed at 32 and passed within 8 months. He fought as long as he could and even with low odds he and my sister wanted to fight and try.
My father was in his late 60s when bloodwork showed elevated PSA. Subsequent biopsies showed cancerous lesions and he underwent radical prostetectomy. Thankfully he is ok now.
My opinion is that when the alternative is physical agony, severely decreased QOL, and or death then increased chance of early detection can make a large difference and should be up to the patients. But ethically I think we should have those options available from the healthcare community regardless of other complications strictly due to the nature and outcomes of many cancers. Even with uncertain accuracies. Few things worse than death IMO.
Again, this does not apply to all scenarios. I realize that is illogical. But I’m not sure how to square that circle yet.