The FDA has just issued an updated black box warning further lowering the hgb goals for these patients from a max of 12g/dL to 11 g/dL as follows:
Chronic Kidney Disease:
• In controlled trials, patients experienced greater risks for death, serious adverse cardiovascular reactions, and stroke when administered erythropoiesis-stimulating agents (ESAs) to target a hemoglobin level of greater than 11 g/dL.
• No trial has identified a hemoglobin target level, ESA dose, or dosing strategy that does not increase these risks.
As WTC seems to continually raise the price of entry,I wonder what really is the price of a Kona slot these days? Does the downhill slide to comfort with no-holds barred cheating start with being ok with riding in a pack of 30 at IMFL, stealing AG or podium places from those who don’t? Just wondering…
SImply that EPO use increases the risk for death, serious adverse cardiovascular reactions, and stroke; there is no known hemoglobin target level, ESA dose, or dosing strategy that does not increase these risks.
It’s my belief that there are a number of AG’s out there doing this stuff for a whole lottat reasons. Just trying to grab a few of 'em by the collar and have them look at the true cost…
I certainly agree with you that EPO abuse occurs … but your warning and studies are related to those with chronic kidney failure … typically on dialysis. I suspect there aren’t many of them competing in ironman
I’m getting old. The 16.8 was 4 years ago! The 15 was two years ago when I was sick for two weeks. I’m looking for my last one this spring… Now you have me worried, and IM Swiss is just around the corner, you bastard!
That’s a huge problem for me because I also have a limited ability to absorb iron. My hematocrit has been down to 10. Of course, I could barely breath there. Now it’s up to an astonishingly high 39, last test. I take huge iron pills every day, but unlike most males I can’t kick up the iron levels. Most males should not be taking iron, I’m advised. For IM Swiss I’m taking about 54 mg of iron a day. This, and my asthma, are the two main reasons why I always finish LAST. (age might be a small factor)
So your hematocrit has varied from 10-49? While I am no expert on the subject I didn’t know you could survive at a level of 10. Did you get a blood transfusion?