Here is the only .02 that I can give you based on my experience with both and a definite lack of ‘technical terms’. Being 6’3" and 210, I wore the Kayano and I did not feel like I had a premium shoe on. Yes it felt good and it helped resolve a lot of the back problems that I experienced with other shoes. I went to a specialty running store and the guy there told me I was crazy and pointed me in the direction of the 2080’s. Felt great and the price tag felt even better. I usually buy them three pairs at a time just in case they become extinct. I have worn the 2100’s and they feel the same for me. No more Kayano.
I know this is probably not as technical as you would like but I saw no one else was giving you any love!!