Does any body know of a Bike Company that makes a Road Frame with 650 wheels in a size 50 to 52cm ?
THANKS BRUCE
Sure, Softride does, not really a road frame though 
I have a Trek 2000, and the Trek 2000 WSD is available with 650’s. I haven’t checked our the rest of their line but other models might be available with 650. You didn’t say if it was for you or a lady friend so maybe this info isn’t helpful.
Oh, I just looked at Cervelo’s site, the P2K is available in 650 up to 54 cm. But, not really a road frame either. Trek might be a good option.
I just remembered, if you have the $$$ you can try a Seven. Those guys measure you, then build you a custom frame - you can undoubtedly get exactly what you want in a road frame there 