I've removed many nails permanently (matrixectomy), but the vast majority of runners do not need this (ultrarunners, esp the ultra trail guys/gals not withstanding).

However, each time you traumatize a nail, the chance for it to regrow deformed or with a nasty fungal increase increases ... then you might want it permanently removed.

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Fatigue is biochemical, not biomechanical.
- Andrew Coggan, PhD