I think the biggest danger is TSA.
Yes. They have opened my Trico Ironcase every time I’ve flown with a bike.
The advice from someone who’s been doing this a long time: get a hardshell case that is easy to open and close. No air bladders or straps that have to be loosened to unbuckle them or anything like that. TSA will not take the care necessary to reclose the box. Make it easy and the bike will probably arrive undamaged.
When I pack up my Trico Ironcase I leave the straps slightly loose so they are easy to put back together with no adjustment required.
A few years ago I received my case with the straps really loose, I think the TSA was just too lazy to tighten things back up when they were done inspecting. I make it easy for them now.
Also, I’ve had broken buckles the last few times I’ve flown, it’s probably from the handlers.
This is what I’ve replaced the broken ones with:
https://www.rei.com/product/850234/sea-to-summit-1-pin-side-release-field-repair-buckle?sku=8502340005&store=58&cm_mmc=PLA_Google|21700000001700551_8502340005|92700058213424423|BA|71700000074422454&gclid=Cj0KCQiAu62QBhC7ARIsALXijXQm2N8utRYw2fTGh9H9PxqnmHBsV4EEe7-5Atdnwyq9q_ld552XyKEaAnvWEALw_wcB&gclsrc=aw.ds