When you measure with weights - do you use a series of weights like 5/15/25/35 pounds? Do you check the R and L crank and average them? How close should the L and R measurements be?
I’ve used 25# and 50# and I typically just check the R crank. I didn’t see any meaningful difference between the R and L.
Do the measurements change much from ring to ring and cog to cog?
Ring to ring? Yes (but only by <1% or so). Cog to cog? Not that I’ve seen. I have done “sweeps” across the cogs in the past just to see if it affected the PT wheel at all.
I assume as it gets hotter with Quarq and other SRM’s - that the offset should always drop lower?
Dunno…I don’t really pay attention to which way the offset goes since it basically just “bounces around” within a 5-10 “unit” window. And, like I said earlier, it’s not that much of a concern since I can just backpedal and zero it whenever I feel like it 
How do you do the weight thing with a PT? Is it exactly the same? Do you need to correct for drive chain losses or not as nothing moves?
The same…and actually, I use the PT wheel as the “guide” to tell me when I have the weight is at “max torque”. With the PT in “torque mode”, you see a live readout of the torque. I can slowly lift the weights up from the floor by rotating the wheel backwards (bike is in a trainer) and then I SLOWLY rotate and hold until I find the max torque reading. At that point, I clamp on the rear brake to hold it in place and then take an offset reading of the CinQo.
Since the drivetrain isn’t moving, there are no frictional losses. The torque is the torque. You do have to “correct” for the gear ratio to get the expected torque at the rear hub though.
Last one: SRM said that I can change chainrings and it won’t affect the slope. Think thats true or false?
They might say that…but I think I’d still check it…especially since you can change it if it’s off with the SRM, right? I think this would depend on what chainrings you’re talking about. For example, going from a “spidery” road chainring to a solid, machined, TT chainring I think I would expect to see some differences.
I guess I’d go back to the old engineering adage “When you change something, something typically changes” as a guide in that case 
Dave