Ditto what the two guys before said. Town lake is really nice with some good city, and other, scenery.
There are several greenbelts that have much more natural scenery that are really nice runs. Barton Creek Greenbelt is really nice with everything from rocky sections, to smooth dirt sections. It's best to run that one in the morning before the weekend crowds come out. It's right downtown and the bonus is that you can take a dip in Barton Springs afterwards to cool off.
Maps for both Town Lake and Barton Creek are posted to the Run-Tex website.
There are a couple of others that are much more rugged--Bull Creek and Emma Long, both on the West/Northwest side of town near the Arboretum area. Neither of those are mapped out as well, so it's possible to get a little turned around. Enjoy it. This weekend or which?
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