I have the same bike, I moved the set screws back with the 25c larger tires because even with a small gap little stones will be picked up and scratch their way to ejection at the BB. I would give it a little more room.

Probably a good idea. It caught my eye after last ride,which was muddy, and there was a line of mud in the wheel well probably from crap catching on the tire and rubbing on that area.

Looks pretty tight. 3mm clearance is a good rule of thumb, for both chainstays (sides) and the seat tube. See if you can slide a 3mm allen key in there and use that as a guide. That looks more like <2mm but hard to tell without measuring.

That’s a good tip. I’ll try that

I have 25C, I have to move the screws almost all the way out. I have about 3-4mm clearance.

I have a 2016 P2 and moved the dropout screws back a little to fit the 25mm tyres. Every once in a while I hear a rock go in there, but nothing major. Everything else works great