You can use normal brake pads with the Zipp disk so that is not an issue - and other than the question of why mix 'em - why not?

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What if the Hokey Pokey is what it is all about?

Why not? The only drawback might be if you plan on bringing spares, you just have to bring a tubular and clincher tube too, otherwise, not really an issue.

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"Maybe you should just run faster..." TM

I would second what JM said... a spare tire, (or two) and tubes is a lot of crap tp haul around.

Other than that What advantage is there to runnign wuch a set up? I really can only think about negatives

Other than the fact that it's a royal pain in the ass? No reason. There certainly aren't any safety concerns (that I'm aware of) such as you'd get when mixing radial and bias-ply tyres on a car... But as other posters have mentioned, you have to carry 2x the backup materials to get you home if you flat out. If you're racing a flat IM course and those are the best wheels available to you, it might be worth it. But you'll have to decide on the tradeoff between running fast wheels, and carrying a lot of junk with you.

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<If you're gonna be dumb, you gotta be tough>
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