Both are good wheelsets. The Spinergy would be slightly lighter and the Ritchey slightly more aero. But there isn't much to choose between them.

The bigger difference is the frames. There really is no contest between the frames. The Cervelo frame is much better designed in terms of aerodynamics, ride quality and weight. Compare the tube shapes and you'll notice the C'dale tubes are twice the thickness and have a round leading edge compared to Cervelo's narrow airfoil shape. Then add the best rear wheel cutout in the biz and internal cable, etc.

As for weight, on our scale the Cervelo P2K frame is about 3/4 of a pound lighter than the Cannondale multisport frame.

You can always change the saddle, wheels, anything else down the road if you like, but your frame is forever!

To me...there is no question... Cervelo...Cannondale has no soul

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What if the Hokey Pokey is what it is all about?

I have the Cannondale and my girlfriend has the Cervelo (same size and both fit me great with some minor aerobar adjustments). I like them both a lot but prefer the Cannondale a bit more as it seems a little stiffer (to me at least and I like that). Just make sure you swap out the Profile Carbon Stryke bars for Syntace C-2's as they are alot more comfortable (once again at least to me).