Do you mean Flo disc wheel? If so, there website will come close to answering most of your question (assume Flo 60 is same speed as HED 6). I think aerocoach gives you the answer to your tire/tube question. Then just do the maths. But, disc set up will be faster.

Tubeless is slower than the same tire + latex tubes?!

In most cases, yes. If you use a standard (non tubeless version) of a very low friction tire).

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Use a rear disc wheel.

Mostly the question was relating to how much slower the HED 6+ vs flo disc. Looks like about 15 sec over 40k. However the gpk5 are about 5 watts faster than the gp 4k. The tubeless vs latex tubes are about equal according to aero coach. So, I think it is worth the extra 10 sec to go tubeless and skip the disc wheel for this race. I guess all I really need to do is get a tubeless disc wheel now. 🤣

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https://www.strava.com/athletes/23685202

Why don't you put a GP5000 tire on the disc?

That's a good point. I only bought 2 gp 5k tires, which I already mounted tubeless to the HED wheels last week. I probably should've done more research further out. I just wanted to go tubeless after a couple training flats this summer. So, my options are just based on what I currently have in my parts bin. I have a bunch of GP 4k with good life or brand new. This isn't really an A race, but it is a 2020 A race by default.

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https://www.strava.com/athletes/23685202

I'd just go with the Hed's. They are tubeless, so less chance of flatting on the rough roads.

How is a tubeless tire less likely to go flat?

Unless you hit a REALLY big hole that pops off the bead, you won't be pinch flatting on a rock or similar object.

You put down so much power than it likely won’t matter. Just run whatever you want and crush dreams.

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