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No idea on the medical side, but I'm assuming it's nothing to worry about.
1. â€śClenchingâ€ť Quads in the Evening
There is a difference between soreness (which is usually fine) and deep fatigue (which could put you in deep shnike).
If you are lying in bed and your legs are uncomfortable on a cellular levelâ€” difficult-to-pinpoint fatigue that feels deeper than run-of-the-mill sorenessâ€”your body may be having an adverse reaction to training stress.
On a related note, if you find yourself involuntarily flexing your legs throughout the evening, itâ€™s time to back off.
I would say it's fatigue related, even if it's just twitching and not clenching. I sometimes get a twitch by my eye when I don't get enough sleep. Funnily enough, a few weeks ago I was getting that twitching in my quads, and around the same time my run workouts were tanking. I took both of those signs to mean I should get a little more rest.