When does she see the doctor that ordered the test? If she is taking some supplement then that could be the answer. Or if she is too thin then that puts stress on the body, and could cause this.

What does "eats healthy" mean? Those are the two most misused words in the dictionary. You will not get any consensus on that. Seriously. What specifically does she eat? If she's eating grains, sugar, vegetables/seed oils, none of those are healthy. When I eliminated those from my diet, my HDL went up, Triglycerides, BP and fasting blood sugar went down. My ration of HDL to Trig went from over 2.5 to 1.25. I could go on and on. Full disclosure, I will cheat occasionally, but if I was wearing a CGM I'm willing to bet my blood sugar level would not spike very often (will be getting one soon to test).

BTW, with women, menopause can change things.

Do the lab tests over again to make sure they were not flawed before getting too excited.

I agree with this. For the lab values to change suddenly, from labs just six months ago, would most likely require either a huge change in lifestyle (no exercise and absolutely crappy diet) or flawed lab values.

When a pt becomes diabetic total cholesterol goes up and hdl tends to go down. But she isn't frankly diabetic at this point maybe impaired glucose tolerance (prediabetes). Sometimes diabetes doesn't respect the general rules of occurring as adult onset in overweight folks. But probably premature to conclude that. As others have said repeating the labs is likely a good idea. Maybe repeat in a few weeks and if they are similar repeating in 6 months to see if there is a trend. That is assuming everything else is okay on a good systems review and some halfway decent physical exam.

I have found that cholesterol levels don't move very much with dietary changes. Maybe you can get a 10-15 percent change if person goes from average Western diet to a very good diet. So unless your wife is eating a pint of ice cream a night (which I have seen btw) if the changes are real likely not caused by dietary changes.

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They constantly try to escape from the darkness outside and within
Dreaming of systems so perfect that no one will need to be good T.S. Eliot

What’s her family history like?

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Let food be thy medicine...

Why is she getting bloodwork q 6 months? Is there more to the story? Symptoms?

Agree with repeating.

When I see drastic changes like this, my first thought would be lab error. I usually call the lab to double check or reorder the test(s) on the patient. Though, I've seen "zebras," (rare illnesses), but they usually come with some other signs or symptoms.

I thought this was a post about Labrador Retrievers.

That being said, I hope your wife is ok.

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Tough Times Don't Last, Tough People Do.

To me that is the most important. Diet and such will help adjust labs, but genetics still win!!
And to be sure like others said, make sure not a lab error.

Family history is mostly unremarkable but she does have 1 grandfather who died of an MI at a young age(I think before 40). Nobody with diabetes. Her thyroid is fine. She isn’t underweight nor overweight. No changes in diet or exercise over the past year. No supplements. She saw an NP so I had her make a follow up with the doc and re-do labs.

Lab looks prediabetic. As previously posters have mentioned, re-do the labs. I work in anesthesiology so really not my field. But prediabetes is not uncommon in pregnancy.

I will chime in. Your question was more of a why. At this stage and with her age the overall picture would be one of trends. Based on a single set of bloods it would be unwise to immediately institute treatment, I would be more interested In how they trend over time in her situation. She is young and a brief period of abnormal bloods is unlikely to do her long term harm. I would continue to observe and see what comes with the next set of bloods in either 3 or 6 months time...

As others have said, this could just be a blip. But thought I would add.
-I am female
-40 years pescatarian, no dairy
-9x Kona qualifier, fit my entire adult life.
-I had a heart attack this past May. They found 90% blockage in my LAD and put in a stent.
-I told my cardiologist that I was already doing everything I could with diet, meditation, exercise, etc. "nothing more I could do."
-I read "How Not to Die" (Dr. Michael Greger), "Reverse it" (Dr. Dean Ornish), and Dr. Caldwell Esselstyn "Prevent and Reverse Heart Disease"

A couple things:
1. Women are underdiagnosed and misdiagnosed about heart disease A LOT, even though it is the #1 killer of women, more than all cancers combined. (I had bad labs 10 years ago and my cardiologist then did nothing).
2. I downplayed my family history/was unclear about it. Be sure your wife gets clear about who in her family not only had an MI, but also who was/is on medications for blood pressure, cholesterol. This includes aunts/uncles/grandparents, etc. I realize now probably hypercholesteralemia in my family.
3. I had way too much sugar in my diet for training and with the above books, realized that foods that people without the disease can eat with no harm, I cannot. So, have cleaned up my diet beyond what I knew before.

In 4.5 weeks on no statin, my numbers went from:
Total 195 to 162
LDL 113 to 86
I consulted with a sports cardiologist at the Cleveland Clinic, and we have added in a low dose statin. She wants me to get my total down below 150 and LDL below 70 to reverse the disease.

All the best and feel free to DM if I can be of any help.

Could be a bad lab test.....don't stress yet.

or

Has she had an HCG test?

hate to open this can of worms (not really), but sounds like a keto diet

Hasn’t had a pregnancy test but does have an IUD. Maybe worth double checking

Thanks for sharing. I’ll be sure to pass your story on. Did you try the Ornish diet? I’ve heard it’s extremely difficult to follow

Not keto

[Thanks for sharing. I’ll be sure to pass your story on. Did you try the Ornish diet? I’ve heard it’s extremely difficult to follow[/quote]
Well, Michael Greger calls it evidence based eating. My nutrition changes have been fantastic. I am eating way more volume of food, way more variety, and way better tasting food than ever. I am super motivated because:
1. I don't want to have another heart attack, I may not survive the next one. And I don't want to have a stroke.
2. I had a highly negative reaction to a high dose statin they put me on post stent. I couldn't live like that, let alone train and race feeling like that. So, low dose statin and great nutrition is working really well for me.

Not a doc - she's young for perimenopausal stuff but those lab stats look a lot like what happens during menopause so maybe loop in her OB or Endocrine folks (hormone specialist)?

I am not a doctor. Most doctors and cardiologists follow the "lipid hypothesis" (also known as the cholesterol hypothesis), which is a medical theory postulating a link between blood cholesterol levels and occurrence of heart disease. This is why they prescribe statins.

There is growing support within a segment of the medical community that the lipid hypothesis is false, that atherosclerosis is caused by another mechanism. Something causes damage to the artery, which the body attempts to repair, and using cholesterol do it. There are many things that can cause this: smoking, frequently spiking blood sugar levels, high blood pressure, including while exercising, etc.... In my personal experience, if you combine lots of endurance training with a bad, carb heavy diet, you are activating a silent killer.


If you're open to "critical thinking", a process which involves 1. challenge assumptions, 2. reason through logic, 3. get diversified opinions, I'll give you a few things to look into. Check out the Fat Emperor with Ivor Cummins, thefatemperor.com. He also has a podcast, which is also on YouTube. Look into the work of Dr. Ken Berry, author of "Lies my doctor told me."


Dr. Michael Gregor is a joke. Have you seen what he looks like? He has NO muscle mass. If you want to wither away, go ahead and follow him and do what he says. BTW, I'd love to see his blood work and have him take a Dexa scan so you could see his bone and muscle density. I don't take health advice from people who don't look like how I want to look.


Seriously, get diversified opinions. The current "standard of care" is wrong. It has been corrupted by money. Think about this. Heart disease was rare one hundred years ago. Now its the number one killer. What has changed? Consumption of processed foods, grains, sugar, processed vegetable oils. Reduced consumption of animal foods and fats. The average American gets 700 calories per day from processed vegetable oils. They didn't exist until 150 years ago.


Don't believe a single word I say, check it out for yourself, but have an open mind. PM me if you want to hear more info.