Feel like if you really read anything you’d get freaked out. I’ve used 2k in rattle can where you break the ball and only good one time. I probably used a mask but don’t think it was anything more than normal paint.

Now making carbon molds using gel coat? That’ll light you up!

Polyester resin is hideous. I like the smell of epoxy, though.

I'm sanding and repainting a frame and will use 2K primer and clearcoat. I'll use a respirator and follow the instructions. I'm a materials scientist in aerospace and deal with hazardous chemicals all the time so I have no concern; as long as you respect them and follow the recommendations using proper PPE, you're good to go.