What are you worried about, in particular? If you are used to driving long distances, I don't see how it would be a problem.

While I haven't done a two-day drive before a race, I did drive from Philly to Louisville this year for the race which was about an 11 hour drive. Two stops only. I don't think it negatively affected my race at all. Drove home the day after.

I think my biggest worry would be that it would affect my body. Legs in particular. But I figure if I stop and stretch, I should be ok.

I’ve done a few ironmans after 2 days of driving. If you arrive on wed, that should give you plenty of time to recover for th race. Do some short workouts thurs and Friday to wake up your muscles and rest Saturday and kick ass on Sunday

Wear compression socks during the drive. My legs always feel way better that way after long trips

Sound logic above and tracks w/my experience. Actually I did a 2 day drive before IMCDA last year and arrived on Friday in time for packet pickup. KQ'd on Sunday. Full disclosure, a buddy of mine who owns several running stores gave me some special socks that are good for sitting on planes, etc. they go knee high and look somewhat geeky, but...

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I saw this on a white board in a window box at my daughters middle school...
List of what life owes you:
1. __________
2. __________
3. __________