The difference between the different series of aluminiums is the alloying content and workability. That being said, the only aluminium that I can honestly say that I feel a difference from is the Scandium alloyed aluminium, and I think that is from the perspective of being able to use thinner walls.
But the geometry, along with the saddle, seat post, tyre, and bar tape is really the factor, and most people would not know the difference in frame materials until they have spent over 1K miles and every dimension and component was the same.
But the geometry, along with the saddle, seat post, tyre, and bar tape is really the factor, and most people would not know the difference in frame materials until they have spent over 1K miles and every dimension and component was the same.