A 404 front/808 rear is certainly a safe wheel choice for this race. If you're a confident bike handler and the winds are down, 808 front/rear wouldn't be a problem at all. However the weather can be hit or miss in September, so even though the weather has been good in recent years, there's a chance that it could be cold/wet with relatively high winds.

Last year I drove to the race and took two front wheels and made my final choice on race morning (ENVE 7.8's) according to the forecasted conditions. If you're flying to the race and can only take one set of wheels, I'd recommend the 404/808 for peace of mind. The roads are in mostly good condition, but I'd still recommend running wider tyres for both comfort and handling.

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VALÄ’RE | YouTube

Thanks I'm driving from London so will take both and make a choice the day before