Hello All,
These articles might be of interest ...... since even for those that do not drink coffee ..... as we get caffeine from dark chocolate, gels, soft drinks, and other sources.
https://www.washingtonpost.com/...m_term=.025422be5e1e
Excerpt:
"WADA added caffeine to its Monitoring Program for 2017 so experts could study whether athletes are using the substance “with the intent of enhancing performance.”
WADA’s study will continue through September, at which point the agency will issue a three-month notice that the substance will be added to the Prohibited List the following year. To be added to the prohibited list, the substance must meet two or three criteria: 1) It has the potential to enhance performance; 2) It poses a health risk to athletes; and/or 3) It violates “the spirit of sport.”
Caffeine has been a prohibited substance before, but it was removed in 2003 to prevent athletes “who … drink cola or coffee from testing positive to banned substances,” Agence France-Presse reported at the time."
https://www.outsideonline.com/...faster-others-slower
Excerpts:
"But a few years ago, researchers started to look more closely at the individual variability in response to caffeine. Every study has some more or less random scatter in its results: If the average improvement is 3 percent, some people might actually get 6 percent better, while others don’t improve at all. But not all scatter is random.
A few years ago, evidence started to emerge that some people were consistently more likely to benefit from caffeine than others, and some might actually get slower after taking caffeine, based on their genetic profile. The biggest study to date on this topic has just been published in Medicine and Science in Sports and Exercise, and the results are striking."
https://www.ncbi.nlm.nih.gov/pubmed/29509641
Excerpt:
"CONCLUSION:
Our findings show that both 2 and 4 mg/kg caffeine improve 10-km cycling time, but only in those with the AA genotype. Caffeine had no effect in those with the AC genotype and diminished performance at 4 mg/kg in those with the CC genotype.
CYP1A2 genotype should be considered when deciding whether an athlete should use caffeine for enhancing endurance performance." [emphasis added]
See test below for $99.00 USD
https://www.genomicexpress.com/.../caffeine-metabolism
Excerpt:
"Do you drink coffee, tea, sodas or eat sweets such as chocolate? Do you consume "energy" drinks? These drinks and candies contain caffeine. While there may be some benefits associated with moderate caffeine consumption, research has documented that individuals with certain genetic variants are at increased risk of health problems when they consume caffeine.
Specifically, people with a particular variant in a cytochrome P450 gene (CYP1A2) may have an increased risk of developing hypertension, non-fatal myocardial infarction (MI; heart attack) or recurrent pregnancy loss, depending on levels of caffeine consumption. By testing for this variant of the CYP1A2 gene, you will learn whether you are a fast or slow metabolizer of caffeine. Slow metabolizers of caffeine may be able to reduce their risk of future health problems by modifying their intake of caffeine. "
Actually it is quite simple ....... polymorphism - the presence of genetic variation within a population, upon which natural selection can operate
https://synapse.koreamed.org/...&vmode=PUBREADER
Cheers, Neal
+1 mph Faster
These articles might be of interest ...... since even for those that do not drink coffee ..... as we get caffeine from dark chocolate, gels, soft drinks, and other sources.
https://www.washingtonpost.com/...m_term=.025422be5e1e
Excerpt:
"WADA added caffeine to its Monitoring Program for 2017 so experts could study whether athletes are using the substance “with the intent of enhancing performance.”
WADA’s study will continue through September, at which point the agency will issue a three-month notice that the substance will be added to the Prohibited List the following year. To be added to the prohibited list, the substance must meet two or three criteria: 1) It has the potential to enhance performance; 2) It poses a health risk to athletes; and/or 3) It violates “the spirit of sport.”
Caffeine has been a prohibited substance before, but it was removed in 2003 to prevent athletes “who … drink cola or coffee from testing positive to banned substances,” Agence France-Presse reported at the time."
https://www.outsideonline.com/...faster-others-slower
Excerpts:
"But a few years ago, researchers started to look more closely at the individual variability in response to caffeine. Every study has some more or less random scatter in its results: If the average improvement is 3 percent, some people might actually get 6 percent better, while others don’t improve at all. But not all scatter is random.
A few years ago, evidence started to emerge that some people were consistently more likely to benefit from caffeine than others, and some might actually get slower after taking caffeine, based on their genetic profile. The biggest study to date on this topic has just been published in Medicine and Science in Sports and Exercise, and the results are striking."
https://www.ncbi.nlm.nih.gov/pubmed/29509641
Excerpt:
"CONCLUSION:
Our findings show that both 2 and 4 mg/kg caffeine improve 10-km cycling time, but only in those with the AA genotype. Caffeine had no effect in those with the AC genotype and diminished performance at 4 mg/kg in those with the CC genotype.
CYP1A2 genotype should be considered when deciding whether an athlete should use caffeine for enhancing endurance performance." [emphasis added]
See test below for $99.00 USD
https://www.genomicexpress.com/.../caffeine-metabolism
Excerpt:
"Do you drink coffee, tea, sodas or eat sweets such as chocolate? Do you consume "energy" drinks? These drinks and candies contain caffeine. While there may be some benefits associated with moderate caffeine consumption, research has documented that individuals with certain genetic variants are at increased risk of health problems when they consume caffeine.
Specifically, people with a particular variant in a cytochrome P450 gene (CYP1A2) may have an increased risk of developing hypertension, non-fatal myocardial infarction (MI; heart attack) or recurrent pregnancy loss, depending on levels of caffeine consumption. By testing for this variant of the CYP1A2 gene, you will learn whether you are a fast or slow metabolizer of caffeine. Slow metabolizers of caffeine may be able to reduce their risk of future health problems by modifying their intake of caffeine. "
Actually it is quite simple ....... polymorphism - the presence of genetic variation within a population, upon which natural selection can operate
https://synapse.koreamed.org/...&vmode=PUBREADER
Cheers, Neal
+1 mph Faster